💼 Full-Time Position

Contract Principal AI/ML Scientist (Antibody Engineering)

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Commonwealth Sciences, Inc.
📍 Boston, Massachusetts, United States
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Location
Boston, United States
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Posted
June 10, 2026
Type
Full-Time
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Full-Time Opportunity: This is a permanent, full-time position with a competitive package and real career growth potential.

Job Description

Position located in Boston, MA

Contract Opportunity

Responsibilities of the Contract Principal AI/ML Scientist (Antibody Engineering):

  • Design and implement the computational platform architecture for antibody discovery, integrating ML/DL models, structural biology tools, and high-throughput screening data analysis into the pipeline

  • Develop and deploy ML models for antibody-antigen binding prediction, affinity maturation, and developability assessment

  • Develop state-of-the-art deep learning models for structure-based antibody design, antibody sequence design, antibody-antigen co-folding, and antibody-antigen binding prediction

  • Lead the integration of AlphaFold, Rosetta Antibody/Rosetta Fold, Boltz-1, and other state-of-the-art protein structure prediction tools into the discovery pipeline

  • Create and maintain computational workflows for analyzing large-scale screening data (phage display, yeast display, ...