Job Description
We are seeking a highly motivated researcher to develop next-generation neuronal actuators based on light-gated ion channels. The ideal candidate will have experience in protein engineering, preferably involving membrane proteins and channelrhodopsins. The project will combine in silico mutagenesis with structure-guided design to identify key residues that enhance light sensitivity and photocurrent amplitude, inspired by naturally occurring photoreceptors in photosynthetic organisms. Engineered variants will be functionally characterized using in vitro reconstitution and automated patch-clamp electrophysiology.
The goal of this position is to engineer novel light-gated actuator with unprecedented photon-sensitivity for use in non-invasive, translational neurotherapies.
The position offers strong opportunities for scientific leadership and career development. The position is placed at the interface between the Prof. Dr. Michael Krieg and Prof. Dr. Nicoletta Liguori l...